Ratchet and Clank are searching the galaxy for some missing heroes, when the duo is captured by Gleeman Vox. A "Deadlock" collar is put on Ratchet to prevent him from escaping, and he is forced to enter Vox's combat show called DreadZone. Ratchet has to complete various missions and objectives to keep up the show's ratings while trying to not be killed by the Exterminators, and he and Clank need to figure out a way to escape. Clank, who is now a mission engineer, will aid Ratchet over the radio in his journey.